Aryl Hydrocarbon Receptors

Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.

Also Known As:

Aryl Hydrocarbon Receptor; Receptors, Aryl Hydrocarbon; AH Receptor; Dioxin Receptor; Polyaromatic Hydrocarbon Receptor; Polyaromatic Hydrocarbon Receptors; Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Receptors, Polyaromatic Hydrocarbon; Receptors, TCDD; TCDD Receptor; Receptor, AH; Receptor, Aryl Hydrocarbon; Receptor, Dioxin; Receptor, Polyaromatic Hydrocarbon; Receptor, TCDD; AH Receptors; Dioxin Receptors; Receptors, AH; Receptors, Dioxin; TCDD Receptors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Transcription Factors: 39842
    - Aryl Hydrocarbon Receptors: 2106
  - Cytoplasmic and Nuclear Receptors: 4079
    - Orphan Nuclear Receptors: 433
      - Aryl Hydrocarbon Receptors: 2106
  - DNA-Binding Proteins: 2079
    - Orphan Nuclear Receptors: 433
      - Aryl Hydrocarbon Receptors: 2106

S Stinchcombe Selected Research

S Stinchcombe Research Topics

Disease

Drug/Important Bio-Agent (IBA)